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Volume 10 (1979)
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Virtual issue
Volume 10, Issue 3
Displaying 1-15 of 15 articles from this issue
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[in Japanese]1979 Volume 10 Issue 3 Pages 301-303
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.301JOURNAL FREE ACCESSDownload PDF (392K) -
Takashi SEKI1979 Volume 10 Issue 3 Pages 305-312
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.305JOURNAL FREE ACCESSThe effects of analgesics were studied in 85 healthy male volunteers between the ages of 20 and 25. Electrical stimulation was applied for 5 sec under a single blind method at a frequency of 400 Hz, width of 0.1 msec and electrical potential of 25, 35 and 55 volts on the forefinger of the subjects. Placebo, 250 mg, 500 mg and 1, 000 mg of acetylsalicylic acid, 500 mg and 1, 000 mg of phenacetin, 100 mg and 200 mg of aminopyrine, 125 mg, 250 mg and 500 mg of mefenamic acid, 12.5 mg and 25 mg of pentazocine, 50 mg and 100 mg of phenobarbital and 100 mg of phenobarbital in combination with 100 mg or 200 mg of aminopyrine were administered orally under a double blind method.
The severity of pain evoked by stimulation at 55 volts was assessed and rated on a scale according to the method of Houde et al.
As a result of this study, it was found that acetylsalicylic acid in a dose of 500 and 1, 000 mg, mefenamic acid in a dose of 250 and 500 mg, pentazocine in a dose of 25 mg and phenobarbital in a dose of 100 mg in combination with aminopyrine at 200 mg were effective in relieving pain statistically significant differences from a placebo, and that the analgesic effect of acetylsalicylic acid was prompt in onset and of short duration, whereas an effect of pain relief of pentazocine was slow in onset and long in duration.View full abstractDownload PDF (932K) -
Takao HATTORI1979 Volume 10 Issue 3 Pages 313-322
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.313JOURNAL FREE ACCESSThe influence of psychotropic drugs upon electrocardiographic findings was studied in 104 hospitalized schizophrenic patients, 52 for each sex, receiving the combination-therapy of psychotropic agents.
The results obtained were as follows:
1) The doses of chlorpromazine, levomepromazine, thioridazine, perphenazine and haloperidol possessed significant correlations with the prolongation of the Q-T interval, and the doses of chlorpromazine, levomepromazine, promethazine and biperiden with the increase in heart rate.
2) The interaction between the dose of promethazine and some factor (s) related with sex showed a significant correlation with the Q-T interval prolongation, and the interaction between the dose of biperiden and some factor (s) related with sex showed with the heart rate increase.
3) With the increase in the doses of major tranquilizers, the frequency of the T-wave change was increased, the Q-T interval was prolonged, and the heart rate was elevated.
4) The correlation of the T-wave change and psychotropic drugs was less evident than those of Q-T interval and of the heart rate.View full abstractDownload PDF (1488K) -
Masatoshi TANAKA, Hiroshi ISOZAKI, Yasushi MIZUKI, Kazutoyo INANAGA, C ...1979 Volume 10 Issue 3 Pages 323-334
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.323JOURNAL FREE ACCESSThe effects of triazolam, a newly developed derivative of the triazolobenzodiazepines, on the averaged photopalpebral reflex (PPR) as well as on self-assessment, were investigated in comparison with those of nitrazepam in eight healthy male subjects aged from 18 to 32 years (mean: 23.8) using a double-blind, cross -over design. Blood was collected from 4 of the subjects for assays of triazolam and nitrazepam in plasma. The peak latencies of PPR were rapidly prolonged in a dose-dependent manner after the administration of triazolam, with the maximum level at 180-240 min and recovering within 360 min. In comparison with triazolam at 0.25 mg and 0.5 mg, nitrazepam at 5 mg prolonged the peak latencies of PPR to a lesser extent, and with a more gradual recovery to the initial level. The course of changes over time for both the latencies and the plasma concentrations of triazolam and nitrazepam showed a striking mutual resemblance. The plasma concentration of triazolam showed a peak level at 180min after administration and was markedly reduced at 360min. In contrast, nitrazepam showed its peak plasma level at 240min, with almost the same value even at 360min. The most frequently observed self-assessments were drowsiness, vagueness, and weakness. With triazolam, these symptoms were noted markedly and dose-dependently; however, by 360min, the symptoms had almost disappeared. These results suggest that triazolam may possess sufficient hypnotic, anxiolytic, and muscle-relaxant clinical effects which are likely to appear rapidly and markedly, peaking at 180-240min and disappearing almost completely within 360min.View full abstractDownload PDF (1469K) -
Masumitsu TAKASUGI, Kazuo MINAKUCHI, Kazuyoshi MIYATA1979 Volume 10 Issue 3 Pages 335-345
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.335JOURNAL FREE ACCESSRecently a large number of drugs are being marketed by various pharmaceutical companies with in fact the same active ingredient. However, the possibility remains of their varying with respect to bioavailability, since a drug's in-vitro dissolution pattern as well as its absorption rate and blood concentration follow-ing intake are greatly influenced by the formulation and process of manufacture.
The present study consists of general pharmaceutical tests of four icommercial brands of diclofenac sodium as well as measurement of their plasma concentra-tions in man, followed by a discussion based on these findings concerning the relationship between their in-vitro pharmaceutical properties and bioavailability.
All brands tested were found to produce almost equivalent results with respect to both contents and disintegration time, but one product did show a difference from the rest in dissolution rate along with a tendency toward slightly lower absorption in the plasma concentration test.View full abstractDownload PDF (1392K) -
Comparison Method through a Double-Blind Controlled Study in Multiple HospitalsYuichi SHIOKAWA, Hiroshi ARITOMI, Nobuya OGAWA1979 Volume 10 Issue 3 Pages 347-365
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.347JOURNAL FREE ACCESSThe efficacy, safety, and usefulness of feprazone on classical and definite rheumatoid arthritis according to ARA diagnostic criteria, were examined by the group comparison method through a double-blind controlled study in multiple hospitals, dosing feprazone (300 mg/day) and phenylbutazone (300 mg/day) as a reference standard for six weeks.
(1) Feprazone was found to be equally or more effective than phenylbutazone on rheumatoid arthritis.
(2) As for safety, it was statistically significant that edema was occurred in feprazone less than phenylbutazone and.gastro-intestinal tolerance was also seemed to be better than it.
Feprazone (28.1%) was lower than phenylbutazone (38.1%) in side effects however, no statistically significant difference was found. The detail investigation revealed no serious side effect caused by feprazone.
(3) Feprazone (68.5%) was higher than phenylbutazone (54.2%) in usefulness, however, no statistically significant difference was found.
Consequently, feprazone was assessed to be equally or more effective on rheumatoid arthritis and safer to use than phenylbutazone.View full abstractDownload PDF (2062K) -
Results of a Multicenter Double-Blind Comparative Study with Diclofenac SodiumTakamasa KAGEYAMA, Yuichi SHIOKAWA1979 Volume 10 Issue 3 Pages 367-380
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.367JOURNAL FREE ACCESSThe clinical usefulness of feprazone on osteoarthritis was examined by a multicenter double-blind comparative study dosing feprazone (300mg/day) and diclofenac sodium (75mg/day).
(1) Both feprazone and diclofenac sodium showed a high improvement rate in efficacy: 81.4% and 82.5% respectively.
(2) The incidence of side effects was 6.7% in feprazone treated group and 13.1% in diclofenac sodium treated group, however, no statistically significant difference was found.
(3) Feprazone was 83.3% and diclofenac sodium was 77.0% in usefulness, however, no statistically significant difference was found.
Consequently, feprazone was assessed to be equal in efficacy and slightly safer to use than dicrofenac sodium in the treatment of osteoarthritis.View full abstractDownload PDF (1645K) -
Torakichi AOKI, Takamasa KAGEYAMA1979 Volume 10 Issue 3 Pages 381-393
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.381JOURNAL FREE ACCESSThe clinical usefulness of feprazone on lumbago was examined by the group comparison method, a double-blind controlled study dosing feprazone (300mg/day) and ibuprofen (600mg/day).
As results, feprazone (300mg/day) showed the same extent of relief on lumbago as that of ibuprofen (600mg/day), which has already been recognized as a highly useful drug to control lumbago.
In feprazone, as for safety, side effects, especially gastro-intestinal disorders, were slightly less than ibuprofen. Thus feprazone was concluded to be a commendable drug for the treatments of lumbago.View full abstractDownload PDF (1405K) -
An examination of its dose equivalent to furosemideTakao SARUTA, Eiichi KATO1979 Volume 10 Issue 3 Pages 395-405
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.395JOURNAL FREE ACCESSIn a comparative study with the use of a signgle-blind, Latin square design, piretanide was given orally at three doses to 8 healthy male volunteers.
(1) The diuretic action of piretanide began within one hour after administration and lasted five or six hours.
(2) There was a close correlation after piretanide between dose and diuretic effect, while no correlation was observed between dose and the excretion of potassium and creatinine.
(3) Six mg of piretanide was as potent as 40 mg of furosemide in terms of diuresis, sodium and chloride excretion.
(4) Piretanide was well-tolerated.View full abstractDownload PDF (1156K) -
A Double Blind Controlled Study with Furosemide TabletsKaizo KOBAYASHI, Mitsuyoshi NAKASHIMA, Masao SHIBATA, Masaaki NAOTSUKA ...1979 Volume 10 Issue 3 Pages 407-424
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.407JOURNAL FREE ACCESSThe objective of this study was to compare the antihypertensive effect, usefulness and side effects (especially pollakiuria and polyuria) of two dosage forms of furosemide by the cross-over method.
1. Antihypertensive effect
Blood-pressure was significantly lowered by both dosage forms compared with pre-treatment values. There was no significant difference between the antihypertensive effect of the two preparations.
2. Side effects
The incidence of pollakiuria and polyuria in the Hoe 058R group was signi- ficantly less than that in the furosemide-tablet group.
3. Usefulness
1) Investigator's evaluation
There was no significant difference between the two forms of furosemide.
2) Central Committee's evaluation
Hoe 058 R was significantly superior to furosemide tablets when admini-stered initially prior to cross-over.View full abstractDownload PDF (2070K) -
ADouble-Blind Controlled Study with TrichlormethiazideTeiryo MAEDA, Yoshiaki MASUYAMA, Shozo KOSHIKAWA, Teizo SANJYO, Akio E ...1979 Volume 10 Issue 3 Pages 425-447
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.425JOURNAL FREE ACCESSThe antihypertensive effect and usefulness of Hos 058 R (H) were compared with those of trichlormethiazide (T) as a control drug under double-blind conditions.
The following results were obtained.
1. Antihypertensive effect
There was no significant difference between Hoe 058 R and trichlormethiazide in the global evaluation of antihypertensive effect. The effects on both systolic and mean blood pressure were significantly greater with T than with II However, there was no significant difference in the effect on diastolic pressure.
2. Laboratory data
The decrease in the serum Cl- level in 8th week was significantly greater in the T-group than in the H-group.The BUN elevation in the T-group was significantly higher than in the H-group.
3. Side effects
The incidence of pollakiuria and polyuria was 7.1% (6/85) in the H-group and 3.7% (3/82) in the T-group.This difference was not significant. No other note-worthy side effects occurred.
4. Usefulness
There was no significant difference between the two groups.View full abstractDownload PDF (2835K) -
[in Japanese]1979 Volume 10 Issue 3 Pages 449-456
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.449JOURNAL FREE ACCESSDownload PDF (1307K) -
[in Japanese]1979 Volume 10 Issue 3 Pages 457-465
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.457JOURNAL FREE ACCESSDownload PDF (1610K) -
[in Japanese]1979 Volume 10 Issue 3 Pages 467-470
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.467JOURNAL FREE ACCESSDownload PDF (503K) -
[in Japanese]1979 Volume 10 Issue 3 Pages 471-479
Published: September 30, 1979
Released on J-STAGE: June 28, 2010
DOIhttps://member-cnki-net-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3999/jscpt.10.471JOURNAL FREE ACCESSDownload PDF (1387K)
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